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Assuming you don't want to do a special build for each user, then: • Generate yourself a secret key for the product • Take the user's name • Concatentate the users name and the secret key and hash with (for example) SHA1 • Unpack the SHA1 hash as an alphanumeric string. This is the individual user's 'Product Key' • Within the program, do the same hash, and compare with the product key. If equal, OK. ![]() But, I repeat: this won't prevent piracy I have recently read that this approach is not cryptographically very sound. But this solution is already weak ( as the software itself has to include the secret key somewhere), so I don't think this discovery invalidates the solution as far as it goes. Just thought I really ought to mention this, though; if you're planning to derive something else from this, beware. A license of Recover My Files is sold with a software activation key. Each computer is identified to the GetData activation server by a 'hardware ID', a unique. If you are still unable to activate online, please try the offline activation method. Software activation works by validating that the software's activation ID. From the PC's hardware configuration are sent to Palisade's activation system during activation. Otherwise, Manual Activation can be done while running the software. I would think that by the time someone is hacking your code (possibly at the assembly level) to find your secret key, they are probably also at the level that they can just bypass your checks entirely. I don't think there's a method of registration so secure that it can survive a good hacker running the program locally. As the original comment said, it's really all about anything that makes it one step harder than simply copying the file. A lot of games these days have given up on copy protection and simply take the game content online, in which case the code is out of the hacker's hands. – Dec 4 '12 at 22:56. 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Komplikasi Komplikasi primer akibat langsung dari status epileptikus Kejang dan status epileptikus menyebabkan kerusakan pada neuron dan memicu reaksi inflamasi, calcium related injury, jejas injury, jejas sitotoksik, perubahan reseptor glutamat dan GABA, serta perubahan lingkungan sel neuron lainnya. Although older definitions of status epilepticus focused on seizures lasting more than 30 minutes, a more practical definition is any individual seizure lasting more than 5 minutes or 2 seizures without full recovery of consciousness. Status epilepticus is defined as continuous seizure activity for greater than 5 minutes, or repeated episodes of seizures without resolution of the postictal period. Indian J Pediatr (2011) 78:219226 DOI 10.1007/s12098-010-0291-ySYMPOSIUM ON PICU PROTOCOLS OF AIIMSStatus EpilepticusDinesh Raj & Sheffali Gulati & Rakesh LodhaReceived: 11 October 2010 / Accepted: 28 October 2010 / Published online: 11 December 2010 # Dr. K C Chaudhuri Foundation 2010Abstract Status epilepticus is a common neurological emergency in childhood and associated with significant morbidity and mortality. Status epilepticus (SE) has been defined as continuous seizure activity lasting more than 30 min or 2 or more seizures in this duration without gaining consciousness between them. However, the operational definition has brought the time down to 5 min. Status epilepticus, Frequency-It is extremely important to diagnose non-convulsive status epilepticus (NCSE). About 20% of patients with status epilepticus, whose convulsions have stopped might continue having electrical NCSE. -27% of patients in coma of unknown origin in Neuro-ICU setting. The seizure, Kernig and Brudzinsky signs)[17,18]. So it's quite rational to consider LP for these children. Although, these are practical guidelines for doing LP in a. Management can be broadly divided into initial stabilization, seizure termination, and evaluation and treatment of the underlying cause. Diagnostic evaluation and seizure control should be achieved simultaneously to improve outcome. Seizure termination is achieved by pharmacotherapy. Benzodiazepines are the first line drugs for SE. Commonly used drugs include lorazepam, diazepam, and midazolam. In children without an IV access, buccal or nasal midazolam or rectal diazepam can be used. Penatalaksanaan Status Epilepticus Pdf DownloadPhenytoin as a second line agent is usually indicated when seizure is not controlled after one or more doses of benzodiazepines. If the seizures continue to persist, valproate, phenobarbitone or levetiracetam is indicated. Midazolam infusion is useful in refractory status epilepticus. Thiopentone, propofol or high dose phenobarbitone are considered for treatment of refractory status epilepticus. ![]() Prolonged SE is associated with higher morbidity and mortality. Long term neurological sequelae include epilepsy, behavioural problems, cognitive decline, and focal neurologic deficits. Keywords Benzodiazepine. Status epilepticus. Valproate Status epilepticus is a common neurological emergency in childhood and associated with significant morbidity andD. Lodha (*) Department of Pediatrics, AIIMS, Ansari Nagar, New Delhi 110029, India e-mail: [email protected]. Protocols need to be developed for its management so that emergency care and pediatric intensive care staff is familiar with its management and therapy is standardised. We discuss a protocol being followed at AIIMS for the management of status epilepticus based on review of available evidence.Definition Status epilepticus has been defined as continuous seizure activity lasting more than 30 min or 2 or more seizures in this duration without gaining consciousness between them [1]. This definition was based on earlier animal data that neuronal damage started beyond 30 min of seizure activity [2, 3] and the evidence that this prolonged duration was associated with increased morbidity and mortality [4]. However, with recent data suggesting that neuronal damage started much early and prolonged seizures are refractory to the first-line therapy, there was need to redefine status epilepticus. It has also been observed that most seizures will terminate on their own within 2 min [5], and if seizure persists beyond 5 min it is unlikely to stop on its own and hence, require therapy for termination. Therefore, the 30 min definition is used for research and epidemiological purposes only and the operational definition has brought the time down to 5 min. So, any patient who presents to the health care facility in a convulsing state should be assumed to be in status epilepticus and managed accordingly.Epidemiology A prospective population based study from North London suggested the incidence of convulsive status epilepticus (CSE) to be between 17 to 23 per 100,000 per year [6]. The220Indian J Pediatr (2011) 78:219226incidence was highest in children younger than 1 year (51 per 100,000 per year) with maximum children in the acute symptomatic group. The most common cause of CSE in this study cohort was prolonged febrile seizure. In our emergency services, 1520 patients present with status epilepticus every month, of which approximately half are first episode status epilepticus (unpublished data).institutions. With such, creating one can easily turn into a daunting process before it even commences. Acupuncture brochures template photoshop. ![]() It has also been observed that often protocols are not followed leading to longer duration of status and higher admission rates to intensive care [15]. Management can be broadly divided into (1) initial stabilization, (2) seizure termination, and (3) evaluation and treatment of the underlying cause. Status Epilepticus ReviewAirway patency can be maintained by oral airway, or other devices. 100% oxygen should be provided to prevent hypoxia. In case of respiratory failure, or Glasgow coma scale score 2 h in 1725%, and >4 h in 10% [4143]. These children usually require aggressive management in pediatric intensive care unit and evaluation by a pediatric neurologist. They often have the systemic complications of status epilepticus, require hemodynamic and respiratory support, need continuous EEG monitoring, and have poor outcome. No randomized clinical trials are available comparing anticonvulsants in RSE, and most of the data comes from retrospective reviews, case series, and audits of treatment protocol. ![]() Drugs used in RSE are levetiracetam, valproate, midazolam infusion, anaesthetic agents (pentobarbital, thiopentone, propofol, and inhaled anaesthetics), high dose phenobarbitone, ketamine, and topiramate. Barbiturate Coma (Thiopental and Pentobarbital) Thiopental and pentobarbital are barbiturate anaesthetics, and have good efficacy in RSE but associated with serious adverse effects. Pentobarbital is not available in India.Indian J Pediatr (2011) 23Pentobarbital is the initial metabolite of thiopental. Status Epilepticus PdfIt has a short elimination half-life and penetrates central nervous system quickly. It gets deposited into fat and is very slowly eliminated after prolonged administration. Thiopental has been used in a loading dose of 35 mg/kg followed by further boluses of 12 mg/kg within 35 min till seizure cessation (maximum dose of 10 mg/kg) followed by a continuous infusion of 35 mg/kg/h [44, 45]. Pentobarbital is administered as 1015 mg/kg initial bolus followed by further 25 mg/kg boluses every 5 min till seizure control followed by a continuous infusion of 13 mg/kg/h [46]. Barbiturate coma is associated with serious side effects including hypotension, respiratory depression, and decreased cardiac contractility. These drugs may also cause suppression of lymphocyte activation which is a cause of concern in critically ill patients [47]. As there may be risk of breakthrough seizures once barbiturate coma is tapered off, it would be advisable to add on other drugs like topiramate (discussed later) or hike the maintenance doses of other AED. Propofol Propofol is an intravenous general anaesthetic, and acts through GABAA receptors via a mechanism probably different from benzodiazepines and barbiturates. It has a short elimination half life and does not get accumulated in fat, allowing rapid awakening after discontinuation of infusion. Status Epilepticus CausesPropofol can cause propofol infusion syndrome in children, characterized by cardiac failure, rhabdomyolysis, metabolic acidosis, renal failure, and sometimes death. Realtek hd audio driver windows xp service pack 2. Because of this reason, propofol is not approved for use as a sedating agent in children less than 16 years of age. |
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